LEPROMIN SENSITIVITY

Lepromin retesting as a factor of lepromin test positivation.

Much has been discussed not only about the nature of the lepromin reaction, but also about the induction of its positivity by previous contact with M. leprae and other mycobacteria. The objective of this paper is to study the reaction of guinea pigs to successive inoculations of lepromin, keeping in mind that the experiment on a laboratory animal permits a better control than on a man. Some aut...

Lepromin Testing with Diluted Antigen

It is now a well-recognized fact that, imperfect as 'modern treatment of leprosy may be, the results of it are making it more and more difficult in most places to obtain bacillus-rich lepromas suitable for makinglepromin. And at the same time more and more stress is being laid on the use of the Mitsuda test, for which that antigen is required. Thus has arisen a new and unprecedented problem. On...

A modification of the lepromin test.

Lepromin is an antigen prepared by grinding 1 'gm. of autocJaved bacteriologically positive tissue in 20 ml. of normal saline, a concen­ tration of 1 :20. The test is made by injecting 0.1 ml. i ntradermally . At the end of 24 to 48 hours, there is a tuberculin like response which rapidly fades, to be succeeded in most instances by a nodular infiltra­ tion which reaches its maximum size in thre...

Lepromin and tuberculin tests in Venezuelan leprosy foci; induction of lepromin reactivity by BCG vaccination.

The work reported in this paper was carried out by the Fourth Antileprosy Service of the Leprosy Division of the Ministry of Health of Venezuela. It was planned for the purpose of studying the lepromin and tuberculin reactions before and after the administration of BCG in a relatively large group of persons living in leprosy foci of rural areas. Statistics regarding the induction of the lepromi...

A study of lepromin in healthy contacts.